gecko snowbound: June 2012

Saturday, June 30, 2012

DA: No charges in leak of Rihanna beating photo

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Source: http://news.yahoo.com/da-no-charges-leak-rihanna-beating-photo-010519348.html

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Russia, US key to last-ditch Syria talks in Geneva

This image made from amateur video released by Shaam News Network and accessed Friday, June 29, 2012, purports to show shelling in Homs, Syria. (AP Photo/Shaam News Network via AP video) THE ASSOCIATED PRESS CANNOT INDEPENDENTLY VERIFY THE CONTENT, DATE, LOCATION OR AUTHENTICITY OF THIS MATERIAL

This image made from amateur video released by Shaam News Network and accessed Friday, June 29, 2012, purports to show shrouded bodies in Douma, a suburb of Damascus, Syria. (AP Photo/Shaam News Network via AP video) THE ASSOCIATED PRESS CANNOT INDEPENDENTLY VERIFY THE CONTENT, DATE, LOCATION OR AUTHENTICITY OF THIS MATERIAL

In this Thursday, June 28, 2012 photo, embers of the Free Syrian Army are seen in a neighborhood of Damascus, Syria. Much of the violence that has gripped Syria has been sanctioned by the government to crush dissent. But rebel fighters are launching increasingly deadly attacks on regime targets, and several huge suicide bombings this year suggest al-Qaida or other extremists are joining the battle. A bomb blast rocked central Damascus on Thursday near a busy market and the country's main justice complex, wounding at least three people and sending a cloud of black smoke into the air. (AP Photo)

GENEVA (AP) ? Russian's desire to keep its last remaining ally in the Middle East collided head-long with the United States' desire to remove President Bashar Assad and replace him with a democracy at a pivotal United Nations-brokered conference Saturday seeking a political solution to the violence in Syria.

Efforts at bridging the Russian-U.S. divide over Syria held the key to international envoy Kofi Annan's plan for easing power away from Assad's grip and ending 16 months of horrific violence in Syria before it erupts into full-blown civil war.

Without agreement among the major powers on how to form a transitional government for Syria, Assad's regime which is Iran's closest ally would be emboldened to try to remain in power indefinitely ? and that would also complicate the U.S. aim of preventing Iran from getting a nuclear weapon.

At talks Friday night, top U.S. and Russian diplomats remained deadlocked over the negotiating text to agree on guidelines and principles for "a Syria-led transition."

Hopes have centered on persuading Russia, which is Syria's most important ally, protector and supplier of arms, to agree to a plan that would end the Assad family dynasty that has ruled Syria for more than four decades. But the Russians want Syria alone to be the master of its fate, at a time when Assad's regime and the opposition are increasingly bitterly polarized.

"Ultimately, we want to stop the bloodshed in Syria. If that comes through political dialogue, we are willing to do that," said Khalid Saleh, a spokesman for the Syrian National Council, a coalition of Syrian opposition groups in Istanbul, Turkey. "We are not willing to negotiate (with) Mr. Assad and those who have murdered Syrians. We are not going to negotiate unless they leave Syria."

The negotiating text for the multinational conference calls for establishing a transitional government of national unity, with full executive powers, that could include members of Assad's government and the opposition and other groups. It would oversee the drafting of a new constitution and elections.

But the text that would serve as the framework for Annan's peace efforts also would "exclude from government those whose continued presence and participation would undermine the credibility of the transition and jeopardize stability and reconciliation."

Foreign ministers from all five of the permanent, veto-wielding members of the U.N. Security Council ? Britain, China, France, Russia and the U.S. ? converged at the U.N.'s European headquarters in the sprawling Palais des Nations overlooking Lake Geneva and Mont Blanc. Russia and China have twice use their council veto to shield Syria from U.N. sanctions.

For his "Action Group on Syria," U.N.-Arab League envoy Annan also invited Turkey, the U.N. secretary-general Ban Ki-moon, the European Union and Iraq, Kuwait and Qatar as heads of three groups within the League of Arab States.

Major regional players Iran and Saudi Arabia were not invited. The Russians objected to the Saudis, who support the Syrian opposition. The U.S. objected to the Islamic Republic, which supports Assad's regime.

Much of the work remains to be hammered out by Russian Foreign Minister Sergey Lavrov and U.S. Secretary of State Hillary Rodham Clinton, who met for an hour in St. Petersburg before sharing dinner Friday before Clinton left Russia. Lavrov predicted the meeting had a "good chance" of finding a way forward, despite the grim conditions on the ground.

Russia insists that outsiders cannot order a political solution for Syria, while the U.S. is adamant that Assad should not be allowed to remain in power at the top of the transitional government.

But Clinton said Thursday in Riga, Latvia, that all participants in the Geneva meeting, including Russia, were on board with the transition plan. She told reporters that the invitations made clear that representatives "were coming on the basis of (Annan's) transition plan."

The uprising in Syria since March of last year has killed some 14,000 people and Syria has shot down a Turkish warplane. Turkey has responded by setting up anti-aircraft guns on its border with Syria. On Friday, Syrian troops shelled a suburb of Damascus, killing an estimated 125 civilians and 60 soldiers.

The United Nations says the violence in Syria has worsened since a cease-fire deal in April and the bloodshed appears to be taking on dangerous sectarian overtones, with growing numbers of Syrians targeted on account of their religion. The increasing militarization of both sides in the conflict has Syria heading toward civil war.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-06-30-EU-Syria-Diplomacy/id-a0d3946dfea147528b9de7535d658c87

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Programmable DNA scissors found for bacterial immune system

ScienceDaily (June 28, 2012) ? Genetic engineers and genomics researchers should welcome the news from the Lawrence Berkeley National Laboratory (Berkeley Lab) where an international team of scientists has discovered a new and possibly more effective means of editing genomes. This discovery holds potentially big implications for advanced biofuels and therapeutic drugs, as genetically modified microorganisms, such as bacteria and fungi, are expected to play a key role in the green chemistry production of these and other valuable chemical products.

Jennifer Doudna, a biochemist with Berkeley Lab's Physical Biosciences Division and professor at the University of California (UC) Berkeley, helped lead the team that identified a double-RNA structure responsible for directing a bacterial protein to cleave foreign DNA at specific nucleotide sequences. Furthermore, the research team found that it is possible to program the protein with a single RNA to enable cleavage of essentially any DNA sequence.

"We've discovered the mechanism behind the RNA-guided cleavage of double-stranded DNA that is central to the bacterial acquired immunity system," says Doudna, who holds appointments with UC Berkeley's Department of Molecular and Cell Biology and Department of Chemistry, and is an investigator with the Howard Hughes Medical Institute (HHMI). "Our results could provide genetic engineers with a new and promising alternative to artificial enzymes for gene targeting and genome editing in bacteria and other cell types."

Doudna is one of two corresponding authors of a paper in the journal Science describing this work titled "A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity." The second corresponding author is Emmanuelle Charpentier of the Laboratory for Molecular Infection Medicine at Sweden's Ume? University. Other co-authors of the paper were Martin Jinek, Krzysztof Chylinski, Ines Fonfara and Michael Hauer.

Bacterial and archaeon microbes face a never-ending onslaught from viruses and invading circles of nucleic acid known as plasmids. To survive, the microbes deploy an adaptive-type nucleic acid-based immune system that revolves around a genetic element known as CRISPR, which stands for Clustered Regularly Interspaced Short Palindromic Repeats. Through the combination of CRISPRs and associated endonucleases, called CRISPR-associated -- "Cas" -- proteins, bacteria and archaeons are able to utilize small customized crRNA molecules (for CRISPR-derived RNA) to target and destroy the DNA of invading viruses and plasmids.

There are three distinct types of CRISPR/Cas immunity systems. Doudna and her colleagues studied the Type II system which relies exclusively upon one family of endonucleases for the targeting and cleaving of foreign DNA, the Cas9 proteins.

"For the Type II CRISPR/Cas system, we found that crRNA connects via base-pairs with a trans-activating RNA (tracrRNA), to form a two-RNA structure," Doudna says. "These dual RNA molecules (tracrRNA:crRNA) direct Cas9 proteins to introduce double-stranded DNA breaks at specific sites targeted by the crRNA-guide sequence."

Doudna and her colleagues demonstrated that the dual tracrRNA:crRNA molecules can be engineered as a single RNA chimera for site-specific DNA cleavage, opening the door to RNA-programmable genome editing.

"Cas9 binds to the tracrRNA:crRNA complex which in turn directs it to a specific DNA sequence through base-pairing between the crRNA and the target DNA," Doudna says. "Microbes use this elegant mechanism to cleave and destroy viruses and plasmids, but for genome editing, the system could be used to introduce targeted DNA changes into the genome.

Doudna notes that the "beauty of CRISPR loci" is that they can be moved around on plasmids.

"It is well-established that CRISPR systems can be transplanted into heterologous bacterial strains," she says. "Also, there is evidence to suggest that CRISPR loci are horizontally transferred in nature."

Doudna and her colleagues are now in the process of gathering more details on how the RNA-guided cleavage reaction works and testing whether the system will work in eukaryotic organisms including fungi, worms, plants and human cells.

"Although we've not yet demonstrated genome editing, given the mechanism we describe it is now a very real possibility," Doudna says.

This work was funded primarily by the Howard Hughes Medical Institute, the Austrian Science Fund and the Swedish Research Council.

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The above story is reprinted from materials provided by DOE/Lawrence Berkeley National Laboratory.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/nM75pbUCs_Q/120628193020.htm

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Friday, June 29, 2012

Mitt Romney's Remarkable Consistency on Obama and Health Care (Atlantic Politics Channel)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/234783826?client_source=feed&format=rss

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Brave | Arts & Entertainment | South Philly Review

Princess Merida (voiced by Kelly Macdonald) in Pixar?s ?Brave? shows girls that they can shoot a bow and arrow, too.

It may be clearer than ever that Pixar?s golden era went out with ?Toy Story 3,? the jewel in the crown of an animation studio that ruled over its medium for 15 glorious years. But does ?Brave,? Pixar?s new badass-Scottish-lass adventure, deserve to be flogged simply because it?s not ?WALL?E?-level transcendent? Yes and no. Solid yet innocuous, moving yet minimally ambitious, this old-fashioned fantasy is an oxymoronic specimen, aiming for progressiveness while clinging to safe traditions. But it nevertheless offers something rarely seen in the world of toons: A mother-daughter tale that leaves the boys on the side.

Merida (voiced by Kelly Macdonald) is your typical oppressed tomboy princess, a nervy athlete who?d rather fire arrows than follow the rules of her mother (voiced by Emma Thompson), a stern queen trying to marry Merida off. Before you can say ?Mulan,? our free-thinking heroine is pulling an Ariel, consulting a shady witch to ?change her fate.? What results is as zanily random as it is intentionally gender-subverting, and when not inducing yawns with lazy plot offshoots (the male characters simply holler and spar), the combo yields tender common ground for its feuding kinswomen.

Directed by Pixar?s Mark Andrews and Brenda Chapman, ?Brave? follows Disney?s ?Tangled? as a film in which hair proves a benchmark in animation?s evolution (Merida?s springy, scarlet locks are wondrous to behold). But, more importantly, the movie boasts Pixar?s first female lead, a separate benchmark many will view as a blown opportunity.

Andrews and Chapman may pilot their film to an affecting resolution, but their introductory scene of Merida triumphantly scaling a mountain (one of many moments with misty vistas), is hardly a promise that?s kept. ?Brave? is an atmospheric jaunt with quirky flourishes, but its bound to leave the gals in the audience feeling a bit shortchanged. Whereas, say, ?Up? presented a man with startling human complexity, Pixar?s unwittingly regressive 13th feature keeps things light and unchallenging, all while quietly waving a flag of feminism. Instead of passing women the ball, it merely throws them a bone.

Brave

PG
Two reels out of four
Now playing in area theaters

Recommended Rental

The Hunter

R
Available Tuesday

Willem Dafoe fans shouldn?t miss the eco-drama ?The Hunter,? which sees the chameleonic actor take the lead as a sharp-shooting mercenary, tasked to hunt down an endangered animal in Tasmania. Shot on location, the film is predominantly picturesque, and it ably blends environmental themes with taut conflict. Its scattered missteps are overshadowed by Dafoe, who gives a soulful performance as the noirish antihero.

Contact the South Philly Review at editor@southphillyreview.com.

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TheDude said...
Mandy Moore is pretty smokin. I wish I was cool enough to date her. Does anybody know how I can get her number?

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Source: http://www.southphillyreview.com/arts-and-entertainment/Brave-160608485.html

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Dozens wounded as Serbs, Kosovo police clash

Source: http://news.yahoo.com/dozens-wounded-serbs-kosovo-police-clash-145247787.html

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Mom & Dad's 40th Anniversary SURPRISE Party!

One year ago (July 1st), on my parents' 39th wedding anniversary, I called my brother and told him that we had 1 year to plan mom & dad's 40th anniversary SURPRISE party.? He was on board and we quickly started throwing ideas around.? It wasn't until?January that we really started to get the ball rolling, as far as planning goes.
My uncle Steve (mom's brother) was kind enough to allow us to use his gorgeous home.? We also hired "The Taco Man".? There were many details to plan and execute and I can now say that everything turned out PERFECT!? The best part..... THEY WERE ACTUALLY SURPRISED!? I am still shocked that no one blew it.? I didn't think that ever happened anymore.? It seems like someone always spills the beans.?
Here is how it worked:? Cade's birthday is in a few weeks, so I told my parents that we were having a "family only" party at uncle Steve's house for Cade.? I told them that we had to have it a few weeks before his bday since some of Brad's family would be out of town and this was the only weekend that worked.? I wanted my parents to arrive at 1pm, so I told them Cade's bday party started at 2pm, and could they please arrive at 1pm to help Brad & I set up.? They said, "Of course we will help!"? (But really, everyone was arriving at 12:30pm.? So this would give everyone time to arrive before mom & dad arrived at 1pm.)
Onto some pictures....
Here is the cake.? I just LOVED it with the "now and then" pictures!
I also got that photo board that you see in the top left corner.? It is a picture from their honeymoon.? Everyone signed it and it waas a great keepsake for them to remember this day.

A few pictures from "now and then" decorated the patio.

My brother and his wife and son (Chris, Aimee, and Brennan) flew out from Texas to surprise them as well.? Here is Cade whooping it up with his cousin Brennan.? They had a blast together!

We had a video that was a slideshow with a bunch of pictures.? It was set to the song "I Will Be?Here For You" by Christian artist Steven Curtis Chapman.? Here is Cade watching the video....
My parents (and Berkley) watching it...

My bro & I watching....

LOVE this one of my parents and their 3 grandchildren watching.? And how about Cade looking so excited?! :)? He must've seen a picture of himself in there:)

The happy couple.

Our family.?

Mom, dad, my brother, his son, me and my monkeys.

Same people but with my brother's wife Aimee, and my husband Brad.

Here you can see the pool and The Taco Guy setting up.

Cade &Brennan getting pushed in the hammock by auntie Bee Bo!? (This is what I called Beth growing up.? Now the kiddos call her the same thing:)

Nash (my cousin Steph's son), Brennan, and Cade playing ball.

Playing with Blake - or "Beek" as Cade calls him:)

We invited our huge family and also 5 couples that are my parents very best friends.? My parents were SO happy that all of their closest friends were there!? Here?are a bunch of them.

I am SO happy that mom & dad were surprised!? I will post a video soon that shows them walking in and hearing "SURPRISE!".? You can tell by my mom's face that they had no clue.? It was really neat how we let them know that my brother and family had flown in from Texas.? Basically, they were in a back bedroom hiding.? Once we all said, "Surprise!", and our hearts stopped racing, ?my mom said, "Oh my gosh!? Everyone's here.? Is Chris here too?"? I said, "No, but he wanted me to call him so that he could say hi and hear your reaction."? So, I called him right there and my mom was talknig to him and telling him how neat this was, etc.? She then gave the phone to my dad so that he could talk to Chris.? About 2 minutes later, Chris walks out of the room still on the phone!? I thought my parents were going to have a heart attack.? It was SO NEAT!? I will post the video soon!?

Source: http://jamminwiththejacobsens.blogspot.com/2012/06/mom-dads-40th-anniversary-surprise.html

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Thursday, June 28, 2012

Exxon's CEO: Climate, energy fears overblown

By JONATHAN FAHEY, Associated Press

ExxonMobil CEO Rex Tillerson says fears about climate change, drilling, and energy dependence are overblown.

In a speech Wednesday, Tillerson acknowledged that burning of fossil fuels is warming the planet, but said society will be able to adapt. The risks of oil and gas drilling are well understood and can be mitigated, he said. And dependence on other nations for oil is not a concern as long as access to supply is certain, he said.

Tillerson blamed a public that is "illiterate" in science and math, a "lazy" press, and advocacy groups that "manufacture fear" for energy misconceptions in a speech at the Council on Foreign Relations.

He highlighted that huge discoveries of oil and gas in North America have reversed a 20-year decline in U.S. oil production in recent years. He also trumpeted the global oil industry's ability to deliver fuels during a two-year period of dramatic uncertainty in the Middle East, the world's most important oil and gas-producing region.

"No one, anywhere, any place in the world has not been able to get crude oil to fuel their economies," he said.

In his speech and during a question-and-answer session after, he addressed three major energy issues: Climate change, oil and gas drilling pollution, and energy dependence.

Tillerson, in a break with predecessor Lee Raymond, has acknowledged that global temperatures are rising. "Clearly there is going to be an impact," he said Wednesday.

But he questioned the ability of climate models to predict the magnitude of the impact. He said that people would be able to adapt to rising sea levels and changing climates that may force agricultural production to shift.

"We have spent our entire existence adapting. We'll adapt," he said. "It's an engineering problem and there will be an engineering solution."

Andrew Weaver, chairman of climate modeling and analysis at the University of Victoria in Canada, disagreed with Tillerson's characterization of climate modeling. He said modeling can give a very good sense of the type of climate changes that are likely. And he said adapting to those changes will be much more difficult and disruptive than Tillerson seems to be acknowledging.

Steve Coll, author of the recent book "Private Empire: ExxonMobil and American Power," said he was surprised Exxon would already be talking about ways society could adapt to climate change when there is still time to try to avoid its worst effects. Also, he said, research suggests that adapting to climate change could be far more expensive than reducing emissions now. "Moving entire cities would be very expensive," he said.

Legislation or regulation that would help slow the emissions of global warming gases would likely lead to lower demand for oil and gasoline, and could reduce Exxon's profit.

Tillerson expressed frustration at the level of public concern over new drilling techniques that tap natural gas and oil in shale formations under several states. He said environmental advocacy groups that "manufacture fear" have alarmed a public that doesn't understand drilling practices ? or math, science or engineering in general. He blamed "lazy" journalists for producing stories that scare the public but don't investigate the claims of advocacy groups.

Drilling for oil and gas will always involve risks of spills and accidents, he said. But those risks are manageable and worth taking because they are small given the amount of energy they produce.

Drilling in shale formations, he said, only poses a small risk to those living nearby. It is neither life threatening nor long lasting and can be controlled in the event of an accident.

Drillers force millions of gallons of water mixed with sand and some hazardous chemicals into shale formations. The technique breaks up rock and creates escape routes for oil and gas. If the drilling wastewater is not treated properly or if it seeps through cracked drilling pipes, it could contaminate drinking water.

The industry's biggest challenge, he said, is "taking an illiterate public and try to help them understand why we can manage these risks."

Tillerson made a distinction between energy security and energy dependence. He said that energy security ? making sure that the economy has access to energy ? is crucial.

But he said access to energy is not in peril. "Some of the fears around energy security are not well founded," he said.

The quest for energy independence, though, is misguided, he said. It doesn't matter where the U.S. gets oil because crude is priced globally. Even if the U.S. used only oil from North America, a disruption in the Middle East would increase global prices, hurt the U.S. and global economies, and force Americans to pay more at the pump.

Even if the U.S. no longer needed Middle Eastern oil, it would likely want to play a major role in helping maintain the region's security, Tillerson said.?

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Friday, June 22, 2012

Celebrex-derived drug targets common childhood bone tumor

Public release date: 21-Jun-2012
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Contact: Erin Pope
Erin.Pope@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital

Jiayuh Lin, PhD, and colleagues at Nationwide Children's Hospital have developed a drug to target the most common cancerous bone tumor in children, osteosarcoma, using a version of the FDA-approved drug, Celebrex. The team will soon begin testing the drug using human and canine tumor cell lines thanks to a two-year, $200,000 grant from Alex's Lemonade Stand Foundation for Childhood Cancer.

Osteosarcoma is an aggressive bone tumor that usually develops during the period of rapid growth that occurs in adolescence. A signaling pathway known as the STAT3 pathway is common in osteosarcoma and is crucial to tumor formation and cancer progression. Blocking STAT3 signaling is considered a potential approach for treating osteosarcoma; however, few drugs are available that can inhibit STAT3 and be clinically relevant.

"One of the main barriers to developing a clinical drug to inhibit STAT3 is finding lead compounds that exhibit desirable drug properties," says Dr. Lin, who is a principal investigator in the Center for Childhood Cancer at The Research Institute at Nationwide Children's Hospital.

Dr. Lin and associate professor at The Ohio State University College of Pharmacy, Chenglong Li, PhD, have found that developing STAT3-selective inhibitors can be accelerated by pairing a novel STAT3 drug discovery method with drug repositioning techniques to create inhibitors with desirable drug properties. Using this method, Dr. Lin's team has developed a STAT3-selective inhibitor, 8A, using the FDA-approved drug, celecoxib (brand name: Celebrex, Pfizer, New York ). Celecoxib is typically prescribed to relieve pain, tenderness, swelling and symptoms of inflammatory conditions like osteoarthritis. 8A is more potent and selective than celecoxib against STAT3 signaling in osteosarcoma cells.

The new funding will allow Dr. Lin's team to develop two additional 8A analogs that would further increase STAT3 binding, while retaining the drug properties of celecoxib. The team will then test all three versions in human and canine osteosarcoma cell lines and in a mouse tumor model. Future research will include collaboration with Cheryl London, DVM, PhD, at The Ohio State University College of Veterinary Medicine to initiate clinical trials of a lead 8A analog in dogs with spontaneous osteosarcoma. Osteosarcoma in dogs is very similar to osteosarcoma in humans. Trials will provide valuable data for human trials as well as help determine the feasibility of using lead 8A analog to treat these tumors in canines.

"This is a unique approach in osteosarcoma targeted therapy," says Dr. Lin. "We feel confident that our findings will advance the field of childhood osteosarcoma treatments."
###

For more information on Dr. Lin, visit http://www.nationwidechildrens.org/jiayuh-lin
For more information on the Center for Childhood Cancer and Blood Diseases, visit http://www.nationwidechildrens.org/center-for-childhood-cancer
For more information on The Research Institute, visit http://www.nationwidechildrens.org/pediatric-research

[ | E-mail | Share ]
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Celebrex-derived drug targets common childhood bone tumor Public release date: 21-Jun-2012
[ | E-mail | Share ]
Contact: Erin Pope
Erin.Pope@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital

Jiayuh Lin, PhD, and colleagues at Nationwide Children's Hospital have developed a drug to target the most common cancerous bone tumor in children, osteosarcoma, using a version of the FDA-approved drug, Celebrex. The team will soon begin testing the drug using human and canine tumor cell lines thanks to a two-year, $200,000 grant from Alex's Lemonade Stand Foundation for Childhood Cancer.

Osteosarcoma is an aggressive bone tumor that usually develops during the period of rapid growth that occurs in adolescence. A signaling pathway known as the STAT3 pathway is common in osteosarcoma and is crucial to tumor formation and cancer progression. Blocking STAT3 signaling is considered a potential approach for treating osteosarcoma; however, few drugs are available that can inhibit STAT3 and be clinically relevant.

"One of the main barriers to developing a clinical drug to inhibit STAT3 is finding lead compounds that exhibit desirable drug properties," says Dr. Lin, who is a principal investigator in the Center for Childhood Cancer at The Research Institute at Nationwide Children's Hospital.

Dr. Lin and associate professor at The Ohio State University College of Pharmacy, Chenglong Li, PhD, have found that developing STAT3-selective inhibitors can be accelerated by pairing a novel STAT3 drug discovery method with drug repositioning techniques to create inhibitors with desirable drug properties. Using this method, Dr. Lin's team has developed a STAT3-selective inhibitor, 8A, using the FDA-approved drug, celecoxib (brand name: Celebrex, Pfizer, New York ). Celecoxib is typically prescribed to relieve pain, tenderness, swelling and symptoms of inflammatory conditions like osteoarthritis. 8A is more potent and selective than celecoxib against STAT3 signaling in osteosarcoma cells.

The new funding will allow Dr. Lin's team to develop two additional 8A analogs that would further increase STAT3 binding, while retaining the drug properties of celecoxib. The team will then test all three versions in human and canine osteosarcoma cell lines and in a mouse tumor model. Future research will include collaboration with Cheryl London, DVM, PhD, at The Ohio State University College of Veterinary Medicine to initiate clinical trials of a lead 8A analog in dogs with spontaneous osteosarcoma. Osteosarcoma in dogs is very similar to osteosarcoma in humans. Trials will provide valuable data for human trials as well as help determine the feasibility of using lead 8A analog to treat these tumors in canines.

"This is a unique approach in osteosarcoma targeted therapy," says Dr. Lin. "We feel confident that our findings will advance the field of childhood osteosarcoma treatments."
###

For more information on Dr. Lin, visit http://www.nationwidechildrens.org/jiayuh-lin
For more information on the Center for Childhood Cancer and Blood Diseases, visit http://www.nationwidechildrens.org/center-for-childhood-cancer
For more information on The Research Institute, visit http://www.nationwidechildrens.org/pediatric-research

[ | E-mail | Share ]
?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

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?The Ultimate Fighter? makes changes, but will it be enough?

Usually, in the months before the UFC starts taping a season of "The Ultimate Fighter," the show holds open tryouts. Fighters from all over the country flock to hotel ballrooms to try to win the favor of the UFC execs watching their every move.

As the show heads into its 16th season, there were no tryouts. Instead, the UFC asked managers to bring welterweights to Las Vegas for auditions and personal interviews.

"I've never seen them skip the tryout process and fly guys straight in," one manager told MMAjunkie.com.

This isn't the only change coming to the UFC's long-running reality show. As Kevin Iole reported, the UFC is going back to a taped format after the 15th season aired fights live. FX has also decided to keep the show on Friday nights.

Though ratings are up for FX on Friday nights, the ratings for the show are down compared to previous seasons. Attendance and gate from the show's finale were also down.

TUF is first a television show, and two rules have always remained true about the modern television landscape. First, it's hard to keep any show fresh for 16 seasons. Secondly, Friday nights are where ratings go to die. There is not much the UFC can do to get around those truisms.

What other changes should "The Ultimate Fighter" make to get you to tune in? Tell us in the comments, on Facebook or Twitter.

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Thursday, June 21, 2012

Multi-function Anti-pressure - Weight loss Classifieds

Free Classifieds Health & Fitness Weight Loss

The specially designed vacuum pump can quickly improve size and shape or breast, without any aching and health threat, it does not involve silicon injection or pushing and filling bra, it would make you have natural and pretty breast according to physiological period.
1. The vacuum pump can absorb fat particle and liquid, and then make them enter breast tissue and cells, leave breast more developed.
2. Expulse toxin and purify lymphatic system, refine skin pore, re-build skin, improve micro-circulation, enhance collagen elasticity, lift drooping muscle, resist
Wrinkle, activate skin, remove eye bag and double jaw, eliminate wrinkle and telangiectasis, and treat sub-health.
3. Stimulate pituitary to product hormone, enhance muscle tissue elasticity and fiber, resume breast elasticity and softness, lift and develop breast, improve breast shape, leave improve suck nipple, stabilize treatment effect.

4. Expedite fatty acid transformation, safely and effectively remove excessive fat, reduce weight, slim up body, eliminate excessive fat on belly, improve leg shape, firm up skin, it can applied for scrub, point percussion therapy, lymphatic detoxification, treat cellulites, improve buttocks to realize perfect body contour.

IIL Instruction:

(I) Breast Development

1. Choose breast cup according to customers? needs, connect the cup and aspirator socket.
2. Let customers half-sleep to stretch out breast, cover breast with plastic cloth, don?t apply on people with sunken breast.
3. Turn the air pressure knob to the highest point in the cup, turn the strength knob to the lowest point, then press? to choose inspiration and turn the rhythm knob to ?breast lifting? (or press body rhythm 1, body rhythm 2 and breast
lifting alternately).
4. Put the cup on breast, and leave breast and the cup closely touched. For people with different breast sizes, it is suggested to apply the instrument on smaller side for 5 times before applying on two sides together.
5. Adjust strength knob from ?weak? to ?strong?, and then adjust air pressure until customers feel comfortable.
6. After 20 minutes, turn the air pressure knob to the
highest point, turn the strength knob to the lowest point to take off the cup, the apply on breast lifting cream.

(II) Rhythm Massage Treatment (Fingertip Moving)
1. Choose appropriate type ?moving fingertip?, connect the cup and inspiration socket with flexible tube.
2. Turn the air pressure knob to the highest point in the cup, turn the strength knob to the lowest point, then press ?power on? and ?functional choice? to choose inspiration and turn the rhythm knob to ?face rhythm? or ?body rhythm? (or press body rhythm 1, body rhythm 2 alternately, face rhythm I and 2 alternately).
3. Adjust strength knob from ?weak? to ?strong?, and then adjust air pressure until customers feel comfortable.
4. After 20 minutes, turn the air pressure knob to the highest point, and turn the strength knob to the lowest point to take off the moving finger.

(III) Scrub Treatment (Gourd Cup)

1. Choose appropriate type cup, connect the cup and inspiration socket with flexible tube.
2. Turn the air pressure knob to the highest point in the cup, turn the strength knob to the lowest point, then press ?power on? and ?functional choice? to choose inspiration and turn the rhythm knob to ?treatment?.
3. Adjust strength knob from ?weak? to ?strong?, and then adjust air pressure until customers feel comfortable.

(IV) Gas Cup (Long-necked Cup)

1. Choose appropriate type cup, connect the cup and inspiration socket with flexible tube.
2. Turn the air pressure knob to the highest point in the cup; turn the strength knob to the lowest point, then press ?power on? and ?functional choice? to choose inspiration.
3. Adjust strength knob from ?weak? to ?strong?, and then adjust air pressure until customers feel comfortable.
(V) Attention:
1. Keep the machine level to avoid shaking and collision.
2. Turn off the power and pull out plug when washing the machine.
3. People with serious heart disease, diabetes mellitus and hepatitis are not suitable for treatment with the
machine.
4. Women during menstruation and pregnancy are not suitable for treatment.
5. Scrub time should be controlled within 30 minutes with appropriate strength that customers feel comfortable.
6. Don?t apply the machine half hour before or after meais, people with empty stomach, fatigue; insufficient sleeping and weak health are not suitable for treatment.
7. People with and blood productivity and spontaneous hemorrhage are not suitable for treatment, including hemophilia, purpuric disease and leukemia.
8. People with serious skin allergic symptoms or acariasis are not suitable for treatment.
9. People with malignant skin tumor or partial skin canker, fracture, varicosity, partial skin elasticity loss
are not suitable for treatment. People in drunk, thirsty or hungry situation should pay special attention.
10. Wash filter regularly to ensure the machine effect and lifetime.
11. When pairing with essential oil, don?t apply too much essential oil or cosmetics to avoid damage the machine.
12. After application of the machine, turn the air pressure to the lowest point.
13. Don?t apply lymphatic detoxifying treatment when you are annoyed with ymphadenitis.
14. Patients with myocardial infarction, phlebitis depravation and intravenous tumor are not suitable for treatment.
15. Don?t apply the treatment within three weeks after surgery for hyperthyroidism, pregnant women.
16. Patient with serious heart disease, diabetes mellitus and hepatitis are not suitable for scrub treatment.
17. Women during menstruation are not suitable for scrub treatment. Pregnant women can have light scrub treatment to promote blood circulation.
18. The scrub time shall not be too long, about half hour is ok with appropriate strength that customers feel comfortable.
19. Don?t apply the treatment half hour before or after meals, people with empty stomach, fatigue; insufficient sleeping and weak health are not suitable for scrub treatment.
20. After scrub treatment, have a glass of warm water after test for a while, and then have warm hath to enhance the effect.
21. You would feel a little bit aching one or two days after scrub treatment that is normal and would automatically disappear.

Website: http://www.beautymachine.net

Ad Listed On: Jun 20, 2012

Ad Views: 29

Location: ny FL USA

Tags: weight loss classifieds, health & fitness advertisement

Classifieds category: Health & Fitness

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Mom and baby carjacked outside Starbucks

By NBCDFW.com

Dallas police are searching for a man who carjacked a woman and her baby Sunday afternoon after stealing from a nearby Walmart.

Police said the man stole a t-shirt from the store and then jumped into the woman's car in a Starbucks parking lot while police were chasing him.

For more visit NBCDFW.com.

The man didn't realize the woman and her 15-month-old daughter were sitting inside the vehicle, police said.

"I thought we were dead," Kari Kimbler said. "I thought he was going to take us somewhere and dump us off or kill us. I had no idea what was going to happen."

Kimbler said her husband had gone inside the Starbucks when the man jumped in the driver's seat and took off. She said he started driving erratically, going the wrong way down Cockrell Hill Road.

"I started hitting him and beating him and screaming, ?My baby, my baby -- I have my baby. Please let us out. Please dump us out. I don't care where it is. Please let us out,'" Kimbler said.

She said the man initially refused.

"Then momma bear kicked, and I all could think was, 'I've got to protect my baby with all that I have,' and it came out, and I just beat the living daylights out of him as hard as I could -- in his head, just punching in his head, and she was screaming too," Kimbler said.

Kimbler said the man stopped underneath a bridge after five minutes.

"He did pull over," she said. "But as I was getting her out, he pushed us out to get us out and just kept going."

Kimbler said she can breathe easier now that she and her baby are home and safe. But she said the fear of what could have happened is still with her.

"I've told all of my loved ones how much I love them," she said. "And I hug my daughter tighter, and I told her tighter, and I tell her how much mommy and daddy love her."

"I'm just so thankful she and I got out alive," Kimbler said.

Dallas police described the man as Latino, approximately 5-foot-9-inches tall, in his early 30s, who weighs about 185 pounds with a bald head and sleeves of tattoos on both arms. He was last seen wearing a gray Texas Longhorns hat, khaki shorts and a dark-colored shirt.

More content from msnbc.com and NBC News:

Follow US News on msnbc.com on Twitter and Facebook

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Amron Experimental 'Rinser Toothbrush' is back, now with more fountain (video)

The original Rinser Toothbrush was a dental delight. Now, Amron Experimental has updated its classic "Brush & Rinse" for the modern mouth. So, what's new in 2012 for the revolutionary chomper-washer? First of all: Power Fountain. No more lowly trickle of water to chase, this time a proud stream of H2O leaps upwards from its center. Secondly, the heads are now replaceable, meaning you can keep your Brush & Rinse in service much longer. Still have the taste of "unconvinced" in your mouth? Watch the tap of awesome flow in the video after the break. Think this is what your morning routine has been missing? Then head to the source where you can pre-order now for a minty-fresh $22.

Continue reading Amron Experimental 'Rinser Toothbrush' is back, now with more fountain (video)

Amron Experimental 'Rinser Toothbrush' is back, now with more fountain (video) originally appeared on Engadget on Thu, 21 Jun 2012 04:32:00 EDT. Please see our terms for use of feeds.

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Wednesday, June 20, 2012

Bobby Brown and Alicia Etheridge: Married!

Bobby Brown and fiancée Alicia Etheridge got married Monday.

Bobbi Kristina Brown? Not on hand for the Hawaiian celebration.

The R&B star and former husband of Whitney Houston was surrounded by other family and friends, including his older kids Landon, 23, La'Princia, 22, and Bobby Jr., 19, as well as Brown and Alicia Etheredge's only child together, Cassius, 3.

The groom wore a red suit and Adidas sneakers ... obviously.

Bobby, who has been arrested numerous times over the years for suspicion of DUI, not paying child support and more, posted the photo of the wedding party.

The couple became engaged in a very public way in 2010, when Brown popped the question to Etheridge during a New Edition show in Jacksonville, Fla.

Brown has often credited Etheredge with giving him a new lease on life following his 2007 divorce from Whitney Houston, who passed away in February.

Bobbi Kristina Brown, 19, Bobby's daughter with Whitney Houston, is "not on good terms right now" with her dad and was MIA, according to a source.

As for a honeymoon ... Brown and Etheridge, who is also his manager, will continue traveling with the New Edition tour, resuming June 23 in Oakland, Calif.

Congrats.

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Tuesday, June 19, 2012

NY Times: How Mexico's Sinaloa drug cartel makes its billions

Posted: ? 06/18/2012 11:03:45 AM MDT

Fighting the border drug war
Ju?rez homicides lowest in 3 years
Report: Human rights issues linked to Mexico's fight against drug cartels
5 burned bodies found in Arizona may be latest drug violence
Gunmen kill 11 in drug rehab center in northern Mexico
Beheaded body discovered in Ju?rez
Journalist kidnapped in northern Mexico
2 of 3 municipal cemeteries in Ju?rez nearly at capacity
Mexico drug war's latest toll: 49 headless bodies
NY Times: Slivers of hope amid melancholy in Ju?rez
Eight slain in Ju?rez over weekend
AFP: Nine bodies found hanging off Mexican bridge
Drug war slayings snuffing out news in Mexico
LA Times: Predator drones have yet to prove their worth on border
'El Chapo' Guzman indicted; Sinaloa cartel boss wanted since '01
Mexican general once tied to cartels shot dead
Seven people killed in Ju?rez within 12 hours
U.S. to donate forensic equipment to Chihuahua and Ju?rez
LA Times: Mexico drug cartel leader turns FBI informant
AFP: Two journalists among 15 shot and killed in Mexican bar
Border report: No 'spillover' violence from Mexican drug-cartel wars
Zetas cartel -Mara Salvatruchas alliance in Mexico unites brutal gangs
Expert: Ju?rez pets abandoned after drug war violence
'War on women' in Mexico described as growing worse since escalation of drug war
Alleged mastermind in Mexican casino arson killed
Experts: Drug violence key in Mexico vote
Ju?rez police officers should accept these are dangerous times, Ju?rez mayor says
Ju?rez authorities say police officers overlook their own safety
NPR review: Death, drugs, 'Salvation and Soccer' in Ju?rez
Mexican exiles denounce Ju?rez mayor; watch video
Jailed Sinaloa cartel enforcer accused in 2 area kidnappings
Ju?rez's psyche may suffer from recent slayings' brutality
AP Exclusive: Mexico police nearly nabbed 'El Chapo' Guzman
16 bodies found in northern Mexico graves
Gunbattle kills policewoman in Mexico border town of Piedras Negras
CNN: Residents turn to social media to fight Mexico cartel violence
Ju?rez police officer slain, the first since officers took shelter in hotels
Two men gunned down in south Ju?rez
El Paso Intelligence Center report says contraband-detection device Mexico uses doesn't do its job
Report: Violence endangers Mexico
Ju?rez police arrest extortion gang suspect
DEA accuses former Mexican governor of ties to Zetas and Gulf cartels
Mexican army chief admits mistakes in drug war
US State Department extends Mexico travel warning to 18 states
2 Ju?rez municipal police officers shot, gravely injured in attack
Man finds God, good after life of crime
Asylum in the US: Mexican activist has lost 6 relatives to violence
Ex-gang member now leads church, shelter in Ju?rez
Update: Leyzaola says New Ju?rez Cartel responsible for attacks on Ju?rez police
Police in northern Mexico catch suspect in 75 drug cartel killings
Mexico catches alleged Sinaloa cartel gun runner
Mexican army detains suspected Azteca gang members in Ju?rez
Fear remains, but hope rises: Ju?rez is ghost town no longer
2 bodies left at Mexico mall; drug toll at 47,500
'Family friend' accused of aiding cartel hit squad in Ju?rez wedding party target
Police find 5 severed heads in northern Mexico
Charred body found near town of Guadalupe
Lawmakers ask President Obama to keep troops on border
EFE: Nightlife in Ciudad Juarez begins to recover
Houston Chronicle: Mexico gangster crackdown nails dozens, but still falls short
El Paso man may be leader in Ju?rez drug cartel
Updated: Man in Ju?rez shot to death in carjacking attempt against deputy attorney general's family
NPR: 'El Sicario, Room 164', the (masked) face of drug-war murder
Reuters: Mexico arrests drug dealer linked to boss 'El Chapo' Guzman
NY Times: Ju?rez police chief produces results, scrutiny
Missing Ju?rez police officer found dead and burned
LA Times: Cartels use legitimate trade to launder money, US, Mexico say
EFE: Nephew of Mexican drug kingpin 'El Chapo' Guzman found slain
Fewer immigrants caught, drug seizures rise in El Paso border region, data show
Mexican army finds tunnel near Arizona border
Despite army takeover, fear strong in Mexican town
Seven homicides reported in Ju?rez on Thursday
LA Times: Latest drug tunnel, pot seizures may reflect rise of Sinaloa cartel
Authorities shut down drug tunnel on California-Mexico border, seize 32 tons of marijuana
Ju?rez's funeral industry tries to adapt as number of homicides dies down
4-year-old Ju?rez boy killed in gunfire
Mexico police shoot it out with teen car thieves in Monterrey
Drug war sends emotionally troubled kids to El Paso, other Texas cities
Two Ju?rez police officers killed in Tuesday night ambush
Mexican soldiers find $15 million linked to Sinaloa cartel
Human remains found in northern Mexico pit
Official: Drug cartel tried to skew Mexico vote
Mexican narcocorridos singer Diego Rivas killed
Mexican democracy tested by drug lords in politics
Feds: Leaders of Sinaloa cartel plotted attack against US
Feds use more unmanned aircraft to secure border
Mutilation murders continue: Two dismembered bodies found in Ju?rez
US citizens dying in Mexico: American deaths expected to increase in 2011
Fox News Latino: Mexican drug lord 'El Chapo' Guzman makes Forbes 'Most Powerful' list
Mexico mayor slain campaigning for president's kin
Texas AG asks Obama to take action on border security, claims drug cartel violence threatens US
Texas sheriff labels shootout 'spillover violence'
Mexican drug cartels strengthen ties with US gangs
Dismembered bodies found all over Ju?rez
NY Times: US agencies infiltrating drug cartels across Mexico
Mexico: Drug-detecting device's effectiveness in question
Mexican president: US dumping criminals at border
Mexico's President Calder?n honors Chihuahua police officers killed Wednesday
Prison riot in northern Mexico leaves 7 dead
3 investigators slain in Ju?rez
Ju?rez children trade toy weapons to promote peace
Three Chihuahua state police officials among a dozen killed today in Ju?rez
Mexico authors talk at UTEP summit
Experts: Drug war in Ju?rez bringing increase in mental health problems
Seven people killed in Ju?rez on Sunday
Northern Mexico city's police force held for investigation
Group implores Ju?rez to bolster police force
Mexican authorities arrest 'El Flaco' of the Sinaloa drug cartel
New Ju?rez Cartel shown questioning guard in video
UMC treats fewer from Mexico; costs still high
School threats spread to northern Mexico
Ju?rez lieutenant who was ambushed last Sunday laid to rest
Video: Football team plays on after Ju?rez massacre
10 federal police officers arrested in Ju?rez
Mexico says key Knights Templar drug cartel figure arrested
Reuters: Mexico president hints legalizing drugs may be needed
Congressional hearing talks insecurity on border
Three men gunned down in Ju?rez
Police find body of missing Mexican congressman
Sinaloa cartel pipeline to Philadelphia thwarted
Belize, El Salvador added to US drug blacklist
U.S. State Dept signals Mexico, Afghanistan among top drug-producing countries
Washington Post: In Mexico, a deadly threat to 'scandal mongers' using social media
Mexico police kill 4 gunmen, rescue kidnap victims
Mexican police seize rifles, handguns, grenade at Chihuahua prison
IANS: Six mutilated bodies found in Chihuahua
Three Cereso prison guards killed in Ju?rez
Ju?rez police officer allegedly caught with firearms, drugs
Once a 'goldmine,' violence makes Mercado Ju?rez barren
Trio, guilty of extortion, could be 1st sentenced to life terms in Ju?rez
Count of police slain in Ju?rez hits 36 in '11
Mexican local police battered in drug war
Mexico says US man smuggled grenade parts
President says Mexico will have clean cops
Mexico detains state cop in deadly casino arson
Mexican journalist's political asylum case could be start of new trend
Ju?rez police coordinator killed driving to work
45% in Mexico say cartel fight advancing
Nuevo Leon governor opens corruption probe in deadly casino fire
El Paso-area agents to be featured on 'Border Wars' TV series
5 detained in casino attack that killed 52 in Mexico
Mexican federal police reportedly beat, threaten Ju?rez police spokesman
Arrest made in 9-year-old Ju?rez slaying
Four dead in two separate Ju?rez junkyard attacks
Mexico in Focus: What else do we need to say enough is enough?
Mexico's Human Rights Committee to look into shooting near school in Ju?rez
Shooting in Ju?rez didn't take place at school, officials said
Man hung from Mexico bridge, shot to death
Leader in Ju?rez cartel arrested in Chihuahua City
Mexico's President Felipe Calderon becomes TV adventure guide
$2.3M restored to upgrade Ju?rez police force
Arizona Daily Star: Border agents find drug tunnel in Nogales
Inmate found dead inside Ju?rez Cereso prison
Ju?rez will celebrate Mexican Independence Day in its own streets
Three people shot to death in Ju?rez
Mexican soldiers kill 8 suspected cartel gunmen
Houston Chronicle: Mexico violence dashes soccer field dreams
Woman, man killed by gunfire in Ju?rez
4 Mexican navy personnel kidnapped by drug gangs
Violent weekend in Ju?rez leaves 12 dead
12 dead in rash of killings in Ju?rez
NY Times analysis: Mexico's drug war draws in women
McClatchy: Zetas drug gang taking control of migrant smuggling
AFP: Mexico uncovers tunnel beneath US border
Wealthy Mexicans fly, rather than drive, to Texas
Man, woman among nine killed in Ju?rez on Sunday
NY Times: US widens role in battle against Mexican drug cartels
5 youths slain at hot dog stand in northern Mexico
Report: Mexican drug cartels adopting military tactics
Alleged Ju?rez cartel leader "El Diego" talks candidly in police videos
Trade rep, customs chief to participate in 2011 Border Security Conference at UTEP
Entire police force quits in Mexican city of Ascension
NPR: Business booms on Mexican border despite violence
Documents: Feds allegedly allowed Sinaloa cartel to move cocaine into U.S. for information
McClatchy: Mexico says its arrests weaken top crime gangs
CNN video: Narco films gain popularity in Mexico
Alleged La Linea leader admits to involvement in 2010 Ju?rez car bombing
Study: Mexico homicides rose 23 percent in 2010
Ju?rez security aid loses $4.9M: Gov't says city fell short training police
Ju?rez 'narco manta' threatens DEA agents, US consulate employees
NY Times: Giraffe a sign of hope in Ju?rez
Texas Tribune: Analysts expect Mexican drug violence to continue
Washington Post: Ju?rez police chief brings confidence, and a troubled past
Ju?rez residents to share solutions
DEA arrests La Familia cartel members in El Paso, Alpine
5th guilty plea made in Columbus firearms trafficking
Two police officers among nine killed in Ju?rez in last 24 hours
Mexico cartel issues booklets for proper conduct
Albuquerque mom arrested for alleged marijuana smuggling attempt
Mexican army burns crops of huge marijuana farm
USA Today: On border, peaceful US side torn by Mexican strife

One afternoon last August, at a hospital on the outskirts of Los Angeles, a former beauty queen named Emma Coronel gave birth to a pair of heiresses. The twins, who were delivered at 3:50 and 3:51, respectively, stand to inherit some share of a fortune that Forbes estimates is worth a billion dollars. Coronel's husband, who was not present for the birth, is a legendary tycoon who overcame a penurious rural childhood to establish a wildly successful multinational business. If Coronel elected to leave the entry for "Father" on the birth certificates blank, it was not because of any dispute over patrimony. More likely, she was just skittish about the fact that her husband, Joaqu?n Guzm?n, is the C.E.O. of Mexico's Sinaloa cartel, a man the Treasury Department recently described as the world's most powerful drug trafficker. Guzm?n's organization is responsible for as much as half of the illegal narcotics imported into the United States from Mexico each year; he may well be the most-wanted criminal in this post-Bin Laden world. But his bride is a U.S. citizen with no charges against her. So authorities could only watch as she bundled up her daughters and slipped back across the border to introduce them to their dad.

?? Read more about the Sinaloa drug cartel from the New York Times

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